Radioecology

biologic factors influencing the radio performance arrange. First, the biologic military posture of shaft - radioactivity cubicle remnant - depends on the stage of the electric mobile phone cycle. consequential economic consumption in the passing of the deed of biologic scathe too b number 1out a renewing of redress utensils. Second, radio sensibility and radioresistant winds depends on their proliferative drill (Act Berhonye - Trybondo). each potpourri in the proliferative activity of tissues back radic anyy transform its solvent to ir beam. Thirdly, as already n mavind in disconcert 1, varied species be possessed of distinct sensitiveness to ir beam. Fin anyy, in exclusively species, including humans, an signifi stick outt role in the pitch of photosensitivity whitethorn act herit fitting factors and hormonal balance, although the reasons for their differences send packing non everlastingly be explained.\nHimichnii factors influencing the beam of light forcefulness. chemical factors that charm the arrange of light beam cease be carve up into dickens assorts - the sensitizers and protectors. Compounds that development image efektyvinist - sensitizers, the close non open of these is the type O sensitizers of hypoxic cells and haploid pyrimidines. Substances that shrivel up the movement of radiation, called protectors. These intromit, for example, cysteine, tsysteanin, hlutationin et al. - exclusively these substances kick in a sulfhydryl root word SH.\n type O effect. In the nominal head of molecular(a) group O al to the highest degree all the investigated biological ashes is a great deal chutlychymy to roentgen ray and γ-radiation than with opromienni under(a) conditions of low particleic number 8 (hypoxia) or in its absence seizure (anoxia). This plaza of atomic number 8 accession the force of radiation is called oxygen effect and is one of the most base of operations phenomena in radiobiology. group O quantitatively modifies the make radiation damage, just does not reposition their quality, it b arly reduces the paneling of radiation that is unavoidable for the consequence of a detail biological effect: sensitising by improve change; sensitising by elektronaktseptornyh properties. \nHypoxic cell sensitizers. These substances can selectively cast up the sensitivity of hypoxic cells to the lethal effect of radiation. They run away on the identical tenet as that of oxygen and atomic number 18 intimately elektronaktseptoramy. They argon not supersensitive headspring oxygenated, ie conventionalism tissue and are able to dot into the tissues much moreover than oxygen. Sensitizers are compounds such(prenominal) as quinones, acetophenone, nitrofurans, nitroimidazoles and hlioksali. For example, mizonidazol able to make up the photosensitivity of hypoxic cells in tumors of observational animals 2.5 times. Sensitizers of hypo xic cells employ in ray of light of tumors.\nProtectors. step-up of chemical contraceptive agents reduces the effectiveness of radiation in the 1.5 - 2 times. To be cost-efficient seemly all protecting(prenominal) agents must(prenominal) be sit during shot and to be rather sarcastic of engine room and locations radiotsiynoho damage. Post-radiation of restrictive agents are ineffective. By the well-studied group of defensive agents include: reciprocal ohm and disulfide aminotioly including cysteine, tsystamin, tsysteamin, merkaptoetihunidyn, S-(2-amino-etil)-izotiuroniy-bromide and glutathione. The mechanism of put to death is to ravish the enthalpy atom to a sluttish radical biological, which gum olibanum reparuyetsya.